Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T.

@article{Page2005ExogenousT,
  title={Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T.},
  author={S. Page and J. Amory and F. D. Bowman and B. Anawalt and A. Matsumoto and W. Bremner and J. Tenover},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 3},
  pages={
          1502-10
        }
}
Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass. These changes might improve physical performance and strength; however, it has not been established whether T therapy improves functional outcome in older men. Moreover, concerns exist about the impact of T therapy on the prostate in older men. The administration of finasteride (F), which partially blocks the conversion of T to the more potent androgen, dihydrotestosterone, attenuates… Expand
Testosterone and exercise: Effects on fitness, body composition and strength in middle-to-older aged men with low-normal serum testosterone levels.
TLDR
Exercise training was more effective than T treatment in increasing aerobic capacity and decreasing total and visceral fat mass, and exercise should be evaluated as an anti-ageing intervention in preference to testosterone treatment in men. Expand
Testosterone and growth hormone improve body composition and muscle performance in older men.
TLDR
Supplemental testosterone produced significant gains in total and appendicular lean mass, muscle strength, and aerobic endurance with significant reductions in whole-body and trunk fat. Expand
Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels.
TLDR
T supplementation was well tolerated and improved body composition but had no effect on functional performance, and upper body strength only in nonexercisers compared with placebo. Expand
Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation
TLDR
Despite sizeable increases in LM measurements at week 8, tests of muscle performance did not show substantive improvements at this time point, and T and rhGH supplementation in older community-dwelling men failed to improve lean mass and muscle strength. Expand
Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study.
TLDR
T treatment in intermediate-frail and frail elderly men with low to borderline-low T for 6 months may prevent age-associated loss of lower limb muscle strength and improve body composition, quality of life, and physical function. Expand
Effects of a Supraphysiologic Dose of Testosterone on Physical Function, Muscle Performance, Mood, and Fatigue in Men with Human Immunodeficiency Virus Associated Weight Loss
ABSTRACT Context. Testosterone increases fat-free mass (FFM) in HIV-infected men, but its effects on muscle performance, physical function, mood and quality of life are poorly understood. Methods:Expand
Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men?
TLDR
The effects of 6-month T treatment on muscle strength, lean mass, and QoL in frail men are not maintained at 6 months post treatment. Expand
Anabolic applications of androgens for functional limitations associated with aging and chronic illness.
TLDR
Testosterone replacement increases vertebral bone mineral density in young hypogonadal men and older men with low testosterone levels, but it is not known whether testosterone reduces fracture risk. Expand
Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men.
TLDR
Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body FM and increased total body FFM and total body and thigh skeletal muscle mass. Expand
Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss.
TLDR
In HIV-infected men with weight loss, a supraphysiological dose of testosterone significantly increased FFM but did not improve self-reported or performance-based measures of physical function and improvements in mood, fatigue, and quality of life measures in the testosterone group, although clinically important, need further confirmation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone.
TLDR
T therapy in older men with low serum testosterone levels increases vertebral and hip BMD over 36 months, both when administered alone and when combined with F, and suggests that dihydrotestosterone is not essential for the beneficial effects of T on BMD in men. Expand
Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age.
TLDR
It is concluded that increasing the serum testosterone concentrations of normal men over 65 yr of age to the midnormal range for young men decreased fat mass, principally in the arms and legs, and increased lean mass, chiefly in the trunk, but did not increase the strength of knee extension and flexion, as measured by dynamometer. Expand
Effects of testosterone supplementation in the aging male.
  • J. S. Tenover
  • Medicine
  • The Journal of clinical endocrinology and metabolism
  • 1992
TLDR
Short term TE supplementation to healthy older men who have serum T levels near or below the lower limit of normal for young adult men results in an increase in lean body mass and possibly a decline in bone resorption, as assessed by urinary hydroxyproline excretion, with some effect on serum lipoproteins, hematological parameters, and PSA. Expand
The male contraceptive regimen of testosterone and levonorgestrel significantly increases lean mass in healthy young men in 4 weeks, but attenuates a decrease in fat mass induced by testosterone alone.
TLDR
In young eugonadal men, T alone rapidly increasesLean mass and decreases fat mass in 4-8 wk; 2) T+LNG rapidly increases lean mass, but has no effect on fat mass; and 3) LNG alone increases fat mass, suggesting that androgen-based male hormonal contraceptives might have favorable effects on body composition. Expand
Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men.
TLDR
It is concluded that 1 month of GH and/or T administration improves certain measures of balance and physical performance in older men and increases muscle IGF-I gene expression. Expand
Androgen replacement therapy to reverse and/or prevent age-associated sarcopenia in men.
  • J. S. Tenover
  • Medicine
  • Bailliere's clinical endocrinology and metabolism
  • 1998
TLDR
Although the data are limited, studies of testosterone replacement in healthy older men with relative testosterone deficiency have demonstrated some modest improvements in muscle mass and strength, although the clinical and functional relevance of the muscle changes have yet to be determined. Expand
Testosterone administration to older men improves muscle function: molecular and physiological mechanisms.
TLDR
It is concluded that physiological and near-physiological increases of testosterone in older men will increase muscle protein anabolism and muscle strength. Expand
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
  • P. Mårin, S. Holmäng, +5 authors P. Björntorp
  • Medicine
  • International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1992
TLDR
It is concluded that testosterone treatment of middle-aged abdominally obese men gives beneficial effects on well-being and the cardiovascular and diabetes risk profile, results similar to those observed after hormonal replacement therapy in postmenopausal women. Expand
Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial.
TLDR
Testosterone supplementation improved strength, increased hemoglobin, and lowered leptin levels in older hypogonadal men in this patient population, and may have a role in the treatment of frailty in males with Hypogonadism. Expand
Effects of finasteride on serum testosterone and body mass index in men with benign prostatic hyperplasia.
TLDR
Finasteride treatment led to a generally modest increase relative to placebo in serum testosterone, with the greatest increases occurring in men with low baseline testosterone levels, which may be related to BMI, which is known to be negatively correlated with serum testosterone levels in men. Expand
...
1
2
3
4
5
...