Exogenous surfactant enhances the delivery of recombinant adenoviral vectors to the lung.

@article{Katkin1997ExogenousSE,
  title={Exogenous surfactant enhances the delivery of recombinant adenoviral vectors to the lung.},
  author={Julie P. Katkin and Richard C. Husser and Claire Langston and Stephen E. Welty},
  journal={Human gene therapy},
  year={1997},
  volume={8 2},
  pages={171-6}
}
Somatic gene therapy for pulmonary diseases must be accomplished in vivo, requiring the spread of a gene transfer vector across a vast expanse of respiratory epithelium. Surfactant, a naturally occurring protein and lipid mixture used to treat the respiratory distress syndrome of prematurity, disperses rapidly and evenly throughout the lung. We employed… CONTINUE READING