Exogenous surfactant as a drug delivery agent.

  title={Exogenous surfactant as a drug delivery agent.},
  author={Jack Haitsma and Ulrike Lachmann and Burkhard Lachmann},
  journal={Advanced drug delivery reviews},
  volume={47 2-3},
Pulmonary surfactant is a complex mixture of lipids and several specific surfactant proteins, which together render it with unique spreading properties and a dynamic surface tension behavior. These characteristics are heralded as ideal for a carrier of choice to instil therapeutic agents into the lung, because this combination enables high local therapeutic levels while minimizing systemic side-effects of the instilled agent. This review outlines the rationale to use exogenous surfactant in… CONTINUE READING