Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2,5-hexanedione-induced testicular atrophy in rats.

@article{Allard1996ExogenousSC,
  title={Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2,5-hexanedione-induced testicular atrophy in rats.},
  author={E K Allard and Kerry T Blanchard and Kim Boekelheide},
  journal={Biology of reproduction},
  year={1996},
  volume={55 1},
  pages={185-93}
}
2,5-Hexanedione (2,5-HD) is a Sertoli cell toxicant that causes irreversible testicular atrophy in rats. After toxicant exposure, only Sertoli cells, stem cells, and a few committed type A spermatogonia remain in the seminiferous epithelium. A majority of the stem cell progeny differentiate into type A spermatogonia, but then, rather than continuing to differentiate, undergo apoptosis. We hypothesized that the cause for germ cell apoptosis was, at least in part, a deficiency in the function of… CONTINUE READING
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