Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides.

@article{Meade2007ExogenousSD,
  title={Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides.},
  author={Bryan R. Meade and Steven F Dowdy},
  journal={Advanced drug delivery reviews},
  year={2007},
  volume={59 2-3},
  pages={134-40}
}
The cellular membrane constitutes an effective barrier that offers protection for the complex, yet highly ordered, intracellular environment that defines the cell. Passage of molecules across this barrier is highly regulated and highly restricted, with molecular size being the most significant criteria. Over the last 15 years, a class of small cationic peptides has been discovered that can defy the rules of membrane passage and can gain access to the intracellular environment. Importantly… CONTINUE READING