Exogenous reelin prevents granule cell dispersion in experimental epilepsy.

@article{Mller2009ExogenousRP,
  title={Exogenous reelin prevents granule cell dispersion in experimental epilepsy.},
  author={Martin C. M{\"u}ller and Matthias Osswald and Stefanie Tinnes and Ute H{\"a}ussler and Anne Kasus Jacobi and Eckart F{\"o}rster and Michael Frotscher and Carola A Haas},
  journal={Experimental neurology},
  year={2009},
  volume={216 2},
  pages={390-7}
}
Temporal lobe epilepsy (TLE) is often accompanied by granule cell dispersion (GCD), a migration defect of granule cells in the dentate gyrus. We have previously shown that a decrease in the expression of reelin, an extracellular matrix protein important for neuronal positioning, is associated with the development of GCD in TLE patients. Here, we used unilateral intrahippocampal injection of kainate (KA) in adult mice which is also associated with GCD formation and a decrease of reelin… CONTINUE READING

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