Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis.

@article{Gomes2006ExogenousPF,
  title={Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis.},
  author={Rachel Novaes Gomes and Fernando A Bozza and Rodrigo Teixeira Amancio and Andr{\'e} Miguel Japiass{\'u} and Rosa C S Vianna and Andr{\'e}a P Larangeira and Juliana M Gouv{\^e}a and Marcela S Bastos and Guy A. Zimmerman and Diana M. Stafforini and Stephen M. Prescott and Patr{\'i}cia Torres Bozza and Hugo Caire de Castro-Faria-Neto},
  journal={Shock},
  year={2006},
  volume={26 1},
  pages={41-9}
}
Current evidence indicates that dysregulation of the host inflammatory response to infectious agents is central to the mortality of patients with sepsis and in those with systemic inflammatory response syndrome. Strategies to block inflammatory mediators, often with complicated outcomes, are currently being investigated as new adjuvant therapies for sepsis. Here, we determined if administration of recombinant platelet-activating factor (rPAF)-acetylhydrolase (rPAF-AH), an enzyme that… CONTINUE READING