Exogenous peptides presented by transporter associated with antigen processing (TAP)-deficient and TAP-competent cells: intracellular loading and kinetics of presentation.

@article{Luft2001ExogenousPP,
  title={Exogenous peptides presented by transporter associated with antigen processing (TAP)-deficient and TAP-competent cells: intracellular loading and kinetics of presentation.},
  author={Thomas Luft and Michael M Rizkalla and Tsin Yee Tai and Qiongyu Chen and Roderick I Macfarlan and Ian D Davis and Eugene Maraskovsky and Jonathan Simon Cebon},
  journal={Journal of immunology},
  year={2001},
  volume={167 5},
  pages={2529-37}
}
This study investigates the differential capacity of TAP-deficient T2 cells, TAP-competent EBV cells, and immature and mature dendritic cells to present peptides to preformed CTL lines. It demonstrates that presentation of exogenous peptides involves peptide uptake and loading onto newly synthesized MHC class I molecules. This mechanism was best demonstrated for low affinity peptides in the presence of irrelevant peptides competing for HLA binding sites. Under these circumstances, inhibition of… CONTINUE READING

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