Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation.

@article{Smith2002ExogenousPD,
  title={Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation.},
  author={David Keith Smith and A. C. Gallimore and Emma L. Jones and Brenda T. Roberts and Janice Lord and Emma Deeks and Vincenzo Cerundolo and Lynne M. Roberts},
  journal={Journal of immunology},
  year={2002},
  volume={169 1},
  pages={
          99-107
        }
}
In this study we demonstrate that a disarmed version of the cytotoxin ricin can deliver exogenous CD8(+) T cell epitopes into the MHC class I-restricted pathway by a TAP-independent, signal peptidase-dependent pathway. Defined viral peptide epitopes genetically fused to the N terminus of an attenuated ricin A subunit (RTA) that was reassociated with its partner B subunit were able to reach the early secretory pathway of sensitive cells, including TAP-deficient cells. Successful processing and… CONTINUE READING

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