Exogenous nitric oxide causes overexpression of TGF-beta1 and overproduction of extracellular matrix in human coronary smooth muscle cells.

@article{Schmidt2003ExogenousNO,
  title={Exogenous nitric oxide causes overexpression of TGF-beta1 and overproduction of extracellular matrix in human coronary smooth muscle cells.},
  author={Annette Schmidt and Sven Geigenmueller and Wolfgang Voelker and Petra Seiler and Eckhart Buddecke},
  journal={Cardiovascular research},
  year={2003},
  volume={58 3},
  pages={671-8}
}
OBJECTIVE Nitric oxide (NO) is a major signalling molecule in the vascular system enhancing vascular smooth muscle cell relaxation and vasodilation. NO donors are the most frequently and repeatedly used drugs for relief from angina pectoris. METHODS We investigated the effects of the synthetic NO donor DETA/NO on cultured human coronary smooth muscle… CONTINUE READING