Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis

@article{Decressac2011ExogenousNY,
  title={Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis},
  author={Mickael Decressac and Ben L C Wright and Belin David and Pam Tyers and Mohamed Jaber and Roger A. Barker and Afsaneh Gaillard},
  journal={Hippocampus},
  year={2011},
  volume={21}
}
Adult neurogenesis mainly occurs in two brain regions, the subventricular zone and the dentate gyrus (DG) of the hippocampus. Neuropeptide Y (NPY) is widely expressed throughout the brain and is known to enhance in vitro hippocampal cell proliferation. Mice lacking either NPY or the Y1 receptor display lower levels of cell proliferation, thereby suggesting a role for NPY in basal in vivo neurogenesis. Here, we investigated whether exogenous NPY stimulates DG progenitors proliferation in vivo… Expand
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