Exogenous myeloperoxidase enhances bacterial phagocytosis and intracellular killing by macrophages.

@article{Lincoln1995ExogenousME,
  title={Exogenous myeloperoxidase enhances bacterial phagocytosis and intracellular killing by macrophages.},
  author={John A. Lincoln and Doris L. Lefkowitz and Thomas P Cain and Alfredo Castro and Kathleen C Mills and Stanley S. Lefkowitz and Nicole Moguilevsky and Alex Bollen},
  journal={Infection and immunity},
  year={1995},
  volume={63 8},
  pages={3042-7}
}
It is well documented that myeloperoxidase (MyPo) contributes to the bacterial activities of neutrophils and monocytes. Since mature macrophages (M phi) are devoid of this enzyme, its participation in M phi-mediated phagocytes and bacterial killing has not been completely defined. The present study demonstrates the exogenously added MyPo, at physiological levels, enhances both phagocytosis and killing of Escherichia coli. Murine peritoneal M phi were exposed to various concentrations of MyPo… CONTINUE READING

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