Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury.

@article{Herrera2007ExogenousMS,
  title={Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury.},
  author={Maria Beatriz Herrera and Benedetta Bussolati and Stefania Bruno and Laura Morando and G Mauriello-Romanazzi and Fiorella Sanavio and Ivan Stamenkovic and Luigi Biancone and Giovanni Camussi},
  journal={Kidney international},
  year={2007},
  volume={72 4},
  pages={430-41}
}
Mesenchymal stem cells (MSC) were recently shown to migrate to injured tissues when transplanted systemically. The mechanisms underlying the migration and homing of these cells is, however, unclear. In this study, we examine the role of CD44 and its major ligand, hyaluronic acid, in the trafficking of intravenously injected MSC in the glycerol-induced mouse model of acute renal failure (ARF). In vitro, hyaluronic acid promoted a dose-dependent migration of the stem cells that was inhibited by… CONTINUE READING
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