Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta‐analysis

@article{Braam2009ExogenousMF,
  title={Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta‐analysis},
  author={W. Braam and M. Smits and R. Didden and H. Korzilius and I. V. Geijlswijk and L. Curfs},
  journal={Developmental Medicine \& Child Neurology},
  year={2009},
  volume={51}
}
Recent meta‐analyses on melatonin has raised doubts as to whether melatonin is effective in treating sleep problems in people without intellectual disabilities. This is in contrast to results of several trials on melatonin in treating sleep problems in individuals with intellectual disabilities. To investigate the efficacy of melatonin in treating sleep problems in individuals with intellectual disabilities, we performed a meta‐analysis of placebo‐controlled randomized trials of melatonin in… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this research is to see the effects (good and bad) of Melatonin CR on sleep in 4-8 year old children with autism spectrum disorders and sleep problems.  
ConditionsSleep Disorder
InterventionDrug
Melatonin for sleep problems in individuals with intellectual disabilities: A study into its effectiveness and clinical aspects
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This dissertation studied the working of melatonin in individuals with intellectual disabilities who have long-term sleep problems and found that melatonin not only turned out effective in the treatment of problems with falling asleep and continuing to sleep, but it also had a positive effect on behaviour problems during the day. Expand
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis
TLDR
Melatonin appeared safe and effective in improving sleep in the studied children, and the overall quality of the evidence was limited due to heterogeneity and inconsistency. Expand
Question 1: Effectiveness of melatonin in treating sleep problems in children with intellectual disability
A 6-year-old boy with mild intellectual disability (ID) attends your clinic with sleep problems ongoing for 2 years; on most nights he has difficulty going to sleep and often wakes during the night.Expand
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The literature supports the existence of a beneficial effect of melatonin on sleep in individuals with ASD, with only few and minor side effects, but considering the small number of studies and their methodological limits, these conclusions cannot yet be regarded as evidence-based. Expand
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Melatonin is generally effective and safe in children with neurodevelopmental conditions and increasing above 6 mg/night adds further benefit only in a small percentage of children. Expand
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Due to the variance in the product, minimal number of studies, adverse effect potential, and lack of data on doses in children, melatonin should be used with caution in children with cerebral palsy. Expand
Use of melatonin for sleep disturbance in a large intellectual disability psychiatry service
TLDR
Patients with autistic spectrum disorder (ASD) or autistic traits were more likely to show a positive response to melatonin than those with learning disability and no ASD/autistic traits and some subjects showed a loss of efficacy after initial response. Expand
Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review
TLDR
Improvement in sleep was greatest in children with autism or other neurodevelopmental disorders, and smaller in adolescents and children with chronic delayed sleep onset, and other drugs and outcomes are inadequately studied. Expand
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial
TLDR
Children gained little additional sleep on melatonin; though they fell asleep significantly faster, waking times became earlier, and child behaviour and family functioning outcomes did not significantly improve. Expand
Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia.
TLDR
Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity. Expand
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