Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD

@article{Sanchez2005ExogenousMI,
  title={Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD},
  author={Raylene J. Sanchez and Chandra Srinivasan and William H. Munroe and Matthew Alan Wallace and Jacob Martins and Tina Y. Kao and Kate Le and Edith Butler Gralla and Joan Selverstone Valentine},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2005},
  volume={10},
  pages={913-923}
}
Yeasts lacking copper-zinc superoxide dismutase (sod1Δ) exhibit a broad range of phenotypes, many of which can be rescued by growth in the presence of high levels of ionic manganese. We undertook a comprehensive survey of the effects of manganese on wild-type and sod1Δ yeasts and found that 5 mM Mn2+ rescued all known growth-related phenotypes, such as slow growth in air, temperature sensitivity, specific amino acid auxotrophies, no growth in high oxygen, poor growth in nonfermentable carbon… CONTINUE READING

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