Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats.


OBJECTIVE Cytotoxic concentrations of nitric oxide are generated luminally at the gastroesophageal junction through the entero-salivary recirculation of dietary nitrate in humans. The site of luminal nitric oxide generation shifts to the lower esophagus when gastric acid is refluxed into the esophagus. The aim of this study was to investigate the influence… (More)
DOI: 10.1080/00365520802699260


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