Exogenous leptin increases lipid peroxidation in the mouse brain.

@article{Kutlu2005ExogenousLI,
  title={Exogenous leptin increases lipid peroxidation in the mouse brain.},
  author={Selim Kutlu and Sinan Canpolat and Mehmet Faruk Aydın and Abdullah Yaşar and Mehmet Tuzcu and Gıyasettin Baydaş},
  journal={The Tohoku journal of experimental medicine},
  year={2005},
  volume={206 3},
  pages={
          233-6
        }
}
Leptin, a hormone produced by the adipose tissues, reduces appetite and food intake, and increases energy expenditures by sending signals to the brain cells. As human obesity is associated with hyperleptinemia and increased systemic oxidative stress, we investigated whether leptin affects lipid peroxidation and antioxidant status in the brain. Leptin was intraperitoneally administered to adult male BALB/c mice (n = 6) at a dose of 40 mug/animal for 5 days, while control mice (n = 6) received… Expand
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