Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice

@article{Wang2018ExogenousLA,
  title={Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice},
  author={Xiaotong Wang and Xiaoke Zhang and Lian Hu and Honggang Li},
  journal={Reproductive Biology and Endocrinology : RB\&E},
  year={2018},
  volume={16}
}
BackgroundSerum leptin levels are augmented in obese infertile men and in men with azoospermia. They also correlate inversely with sperm concentration, motility and normal forms. The mechanisms underlying the adverse effects of excess leptin on male reproductive function remain unclear. The present study aimed to evaluate the effects of exogenous leptin on sperm parameters in mice and to explore the underlying mechanisms.MethodsWe treated normal adult male mice with saline, 0.1, 0.5 or 3 mg/kg… Expand
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Leptin promotes proliferation of neonatal mouse stem/progenitor spermatogonia
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Association between leptin, obesity, hormonal interplay and male infertility
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Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats
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Chronic intermittent hypoxia can cause pathologic damage to rat testes, and Oligozoospermia was highly correlated and regulated by the JAK2/STAT6 signaling pathway; and Chronic intermittent hyp oxia can lead to decreased spermatogenesis in rats. Expand
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TLDR
This work clarified how the hormones in the hypothalamic-pituitary-gonadal axis, including FSH, testosterone and LH, regulate spermatogenesis via the androgen receptor, cAMP/PKA, PI3k/Akt signaling pathways in Sertoli cells. Expand
Leptin is upregulated in epididymitis and promotes apoptosis and IL-1β production in epididymal epithelial cells by activating the NLRP3 inflammasome.
TLDR
It is found that patients with chronic epididymitis presented a significantly higher level of seminal plasma leptin and correlated declined sperm progressive motility, which suggested that leptin may act as a potential evaluation and treatment target for epididymis and male subfertility. Expand
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