Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury.

@article{Lesnefsky1994ExogenousIB,
  title={Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury.},
  author={Edward Joseph Lesnefsky and Jian Ye},
  journal={The American journal of physiology},
  year={1994},
  volume={266 2 Pt 2},
  pages={H384-92}
}
Although previous studies using iron chelators suggest that iron-catalyzed reactions exacerbate myocardial injury, a direct demonstration of the timing, sites, and mechanisms of iron-mediated damage during reperfusion has been lacking. Catalytic doses of redox-active iron react with exogenously administered oxygen radical-generating systems to exacerbate myocardial injury. In an analogous manner, catalytic doses (5 microM) of excess iron present during early reperfusion should augment oxidative… CONTINUE READING
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