Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia–reperfusion injury

@article{Johansen2005ExogenousHS,
  title={Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia–reperfusion injury},
  author={Davis Johansen and Kirsti Ytrehus and FIBiol FESC FAHA G. F. Baxter},
  journal={Basic Research in Cardiology},
  year={2005},
  volume={101},
  pages={53-60}
}
Hydrogen sulfide (H2S) is a gaseous mediator, produced by the metabolic pathways that regulate tissue concentrations of sulfur–containing amino acids. Recent studies indicate that endogenous or exogenous H2S exerts physiological effects in the cardiovascular system of vertebrates, possibly through modulation of KATP channel opening. The present study was undertaken to examine the hypothesis that H2S is cytoprotective against myocardial ischemia–reperfusion injury and that this protective action… CONTINUE READING

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Rat isolated hearts were Langendorff – perfused and underwent 30 min left main coronary artery occlusion and 120 min reperfusion .
Rat isolated hearts were Langendorff – perfused and underwent 30 min left main coronary artery occlusion and 120 min reperfusion .
The present study was undertaken to examine the hypothesis that H2S is cytoprotective against myocardial ischemiareperfusion injury and that this protective action is mediated by KATP opening .
Further work is required to elucidate the potential role of endogenous H2S as a cytoprotective mediator against myocardial ischemiareperfusion injury , the mechanisms regulating its generation , and the nature of its interaction with protein targets such as the KATP channel .
The present study was undertaken to examine the hypothesis that H2S is cytoprotective against myocardial ischemiareperfusion injury and that this protective action is mediated by KATP opening .
Further work is required to elucidate the potential role of endogenous H2S as a cytoprotective mediator against myocardial ischemiareperfusion injury , the mechanisms regulating its generation , and the nature of its interaction with protein targets such as the KATP channel .
Rat isolated hearts were Langendorff – perfused and underwent 30 min left main coronary artery occlusion and 120 min reperfusion .
Rat isolated hearts were Langendorff – perfused and underwent 30 min left main coronary artery occlusion and 120 min reperfusion .
Rat isolated hearts were Langendorff – perfused and underwent 30 min left main coronary artery occlusion and 120 min reperfusion .
Left coronary artery structureAnatomic structure is physical part ofHeart
Rat isolated hearts were Langendorff – perfused and underwent 30 min left main coronary artery occlusion and 120 min reperfusion .
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