Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice.

@article{Liu2017ExogenousHA,
  title={Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice.},
  author={Xiaochen Liu and Jennifer A. McKenzie and Clayton W Maschhoff and Michael James Gardner and M. J. Vaz-da Silva},
  journal={Bone},
  year={2017},
  volume={103},
  pages={
          241-251
        }
}
Fracture healing recapitulates many aspects of developmental osteogenesis. The hedgehog (Hh) signaling pathway, essential to skeletal development, is upregulated during fracture healing, although its importance is unclear. Our goal was to assess the functional importance of Hh signaling in endochondral fracture healing. We created closed, transverse diaphyseal femur fractures in mice, stabilized with an intramedullary pin, and administered a systemic Hh inhibitor or vehicle. Because Hh pathway… CONTINUE READING
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