Exogenous erythropoietin aggravates retinal neovascularizationin a murine model of proliferative retinopathy

@article{Yang2017ExogenousEA,
  title={Exogenous erythropoietin aggravates retinal neovascularizationin a murine model of proliferative retinopathy},
  author={Ning Yang and Wenxi Zhang and Tao He and Yiqiao Xing},
  journal={Turkish journal of medical sciences},
  year={2017},
  volume={47 5},
  pages={
          1642-1650
        }
}
Background/aim: Erythropoietin (EPO) has been proven recently to be a critical mediator in retinal neovascularization (RNV). Previous studies have indicated that the use of recombinant human EPO (rEPO) is a high risk factor in the development of retinopathy of prematurity. In this study, we aimed to investigate the effect of rEPO administration on RNV and its underlying mechanism in a mouse model of oxygen-induced retinopathy (OIR). Materials and methods: A murine model of OIR was used to… CONTINUE READING

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