Exogenous endothelin-1 causes peripheral insulin resistance in healthy humans.

  title={Exogenous endothelin-1 causes peripheral insulin resistance in healthy humans.},
  author={A. Ottosson-Seeberger and Jan M. Lundberg and Anders Alvestrand and Gunvor Ahlborg},
  journal={Acta physiologica Scandinavica},
  volume={161 2},
In states of insulin resistance, increased plasma levels of endothelin-1 and a disturbed vascular reactivity have been reported. In order to investigate the effects of endothelin-1 on peripheral insulin sensitivity and the vasoactive interactions between insulin and endothelin-1, six healthy subjects were studied on two different occasions with the euglycaemic hyperinsulinaemic clamp technique combined with an intravenous infusion of either endothelin-1 (4 pmol kg-1 min-1) or 0.9% sodium… CONTINUE READING


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