Exogenous cytochrome C restores myocardial cytochrome oxidase activity into the late phase of sepsis.

@article{Piel2008ExogenousCC,
  title={Exogenous cytochrome C restores myocardial cytochrome oxidase activity into the late phase of sepsis.},
  author={David A Piel and Clifford S. Deutschman and Richard J Levy},
  journal={Shock},
  year={2008},
  volume={29 5},
  pages={612-6}
}
Mitochondrial dysfunction is thought to play a role in the pathogenesis of a variety of disease states, including sepsis. An acquired defect in oxidative phosphorylation potentially causes sepsis-induced organ dysfunction. Cytochrome oxidase (CcOX), the terminal oxidase of the respiratory chain, is competitively inhibited early in sepsis and progresses, becoming noncompetitive during the late phase. We have previously demonstrated that exogenous cytochrome c can overcome myocardial CcOX… CONTINUE READING

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