Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review

  title={Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review},
  author={S. M. Stout and Nina M Cimino},
  journal={Drug Metabolism Reviews},
  pages={86 - 95}
  • S. M. Stout, Nina M Cimino
  • Published 2014
  • Chemistry, Medicine
  • Drug Metabolism Reviews
  • Abstract Exogenous cannabinoids are structurally and pharmacologically diverse compounds that are widely used. The purpose of this systematic review is to summarize the data characterizing the potential for these compounds to act as substrates, inhibitors, or inducers of human drug metabolizing enzymes, with the aim of clarifying the significance of these properties in clinical care and drug interactions. In vitro data were identified that characterize cytochrome P-450 (CYP-450) enzymes as… CONTINUE READING

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