Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review

@article{Stout2014ExogenousCA,
  title={Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review},
  author={S. M. Stout and Nina M Cimino},
  journal={Drug Metabolism Reviews},
  year={2014},
  volume={46},
  pages={86 - 95}
}
  • S. M. Stout, Nina M Cimino
  • Published 2014
  • Chemistry, Medicine
  • Drug Metabolism Reviews
  • Abstract Exogenous cannabinoids are structurally and pharmacologically diverse compounds that are widely used. The purpose of this systematic review is to summarize the data characterizing the potential for these compounds to act as substrates, inhibitors, or inducers of human drug metabolizing enzymes, with the aim of clarifying the significance of these properties in clinical care and drug interactions. In vitro data were identified that characterize cytochrome P-450 (CYP-450) enzymes as… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 61 REFERENCES
    The Endocannabinoid System as an Emerging Target of Pharmacotherapy
    • 1,532
    • Highly Influential
    • Open Access
    International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
    • 1,092
    • Highly Influential
    • Open Access
    Pharmacology of cannabinoid CB1 and CB2 receptors.
    • 1,308
    Human Cannabinoid Pharmacokinetics
    • 320
    • Open Access
    Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
    • 1,811
    Chemical constituents of marijuana: the complex mixture of natural cannabinoids.
    • 607
    • Open Access
    Beyond THC: The New Generation of Cannabinoid Designer Drugs
    • 312
    • Open Access
    Pharmacology and effects of cannabis: a brief review.
    • 642
    • Open Access