Exogenous but not endogenous substance P releases histamine from isolated human skin fragments.

@article{Tausk1995ExogenousBN,
  title={Exogenous but not endogenous substance P releases histamine from isolated human skin fragments.},
  author={Francisco A Tausk and B J Undem},
  journal={Neuropeptides},
  year={1995},
  volume={29 6},
  pages={351-5}
}
Neuropeptides such as substance P are released from nerve terminals following the stimulation of sensory fibers, and are thought to participate in neurogenic inflammation in the skin; it is often speculated that mast cell activation is an intermediate step in this process. In the present study we addressed this hypothesis using freshly obtained skin… CONTINUE READING