Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

  title={Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism},
  author={Olga Pe{\~n}agarikano and Mar{\'i}a Teresa L{\'a}zaro and Xiao-Hong Lu and Aaron Gordon and Hongmei Dong and Hoa A. Lam and Elior Peles and Nigel T. Maidment and N. P. Murphy and X. William Yang and Peyman Golshani and Daniel H. Geschwind},
  journal={Science Translational Medicine},
Mouse models of neuropsychiatric diseases provide a platform for mechanistic understanding and development of new therapies. We previously demonstrated that knockout of the mouse homolog of CNTNAP2 (contactin-associated protein-like 2), in which mutations cause cortical dysplasia and focal epilepsy (CDFE) syndrome, displays many features that parallel those of the human disorder. Because CDFE has high penetrance for autism spectrum disorder (ASD), we performed an in vivo screen for drugs that… CONTINUE READING


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