Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells.

@article{Damdindorj2012ExogenousAE,
  title={Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells.},
  author={Boldbaatar Damdindorj and Katsuya Dezaki and Tomoyuki Kurashina and Hideyuki Sone and Rauza Sukma Rita and Masafumi Kakei and Toshihiko Yada},
  journal={FEBS letters},
  year={2012},
  volume={586 16},
  pages={
          2555-62
        }
}
We studied interactive effects of insulinotropic GLP-1 and insulinostatic ghrelin on rat pancreatic islets. GLP-1 potentiated glucose-induced insulin release and cAMP production in isolated islets and [Ca(2+)](i) increases in single β-cells, and these potentiations were attenuated by ghrelin. Ghrelin suppressed [Ca(2+)](i) responses to an adenylate cyclase activator forskolin. Moreover, GLP-1-induced insulin release and cAMP production were markedly enhanced by [D-lys(3)]-GHRP-6, a ghrelin… CONTINUE READING

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