Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats.

@article{MartnezMoya2012ExogenousAP,
  title={Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats.},
  author={Patricia Mart{\'i}nez-Moya and Mercedes Ortega-Gonz{\'a}lez and Raquel Fern{\'a}ndez Gonz{\'a}lez and Andrea Anzola and Borja Oc{\'o}n and Cristina Hern{\'a}ndez-Chirlaque and Roc{\'i}o L{\'o}pez-Posadas and Mar{\'i}a Dolores Su{\'a}rez and A. del Hierro Zarzuelo and Olga Mart{\'i}nez-Augustin and Ferm{\'i}n S{\'a}nchez de Medina},
  journal={Pharmacological research},
  year={2012},
  volume={66 2},
  pages={
          144-53
        }
}
Alkaline phosphatase (AP) inactivates bacterial lipopolysaccharide and may therefore be protective. The small intestine and colon express intestinal (IAP) and tissue nonspecific enzyme (TNAP), respectively. The aim of this study was to assess the therapeutic potential of exogenous AP and its complementarity with endogenous enzyme protection in the intestine, as evidenced recently. IAP was given to rats by the oral or intrarectal route (700U/kgday). Oral budesonide (1mg/kgday) was used as a… CONTINUE READING
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