Exogenous Tumor Necrosis Factor-Alpha Mimics Nucleus Pulposus-Induced Neuropathology: Molecular, Histologic, and Behavioral Comparisons in Rats

@article{Igarashi2000ExogenousTN,
  title={Exogenous Tumor Necrosis Factor-Alpha Mimics Nucleus Pulposus-Induced Neuropathology: Molecular, Histologic, and Behavioral Comparisons in Rats},
  author={T. Igarashi and S. Kikuchi and V. Shubayev and R. Myers},
  journal={Spine},
  year={2000},
  volume={25},
  pages={2975-2980}
}
Study Design. This study tested the hypothesis that the 17-kDa form of tumor necrosis factor-alpha is the pathophysiologic agent expressed by herniated nucleus pulposus in vivo that is primarily responsible for the histologic and behavioral manifestations of experimental sciatica associated with herniated lumbar discs. Objective. The authors determined the molecular weight and concentration of active tumor necrosis factor-alpha in rat herniated disc and used exogenous tumor necrosis factor… Expand
274 Citations

Paper Mentions

Interventional Clinical Trial
Tumor necrosis factor (TNF)-alpha has been strongly implicated as a major contributing factor for the development of radiculopathy. In animal studies, the application of TNF-alpha to… Expand
ConditionsSciatica
InterventionDrug
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Tumor Necrosis Factor α and Nucleus‐Pulposus‐Induced Nerve Root Injury
  • 309
Endoneurial injection of TNF-alpha produces neuropathic pain behaviors.
  • 206
  • Highly Influential
...
1
2
3
4
...