Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism.

@article{Qin2004ExogenousNT,
  title={Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism.},
  author={Qining Qin and Xi-ming Yang and Lin Cui and Stuart D. Critz and Michael V. Cohen and Natasha C Browner and Thomas Lincoln and James M. Downey},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 2},
  pages={H712-8}
}
Exogenous nitric oxide (NO) triggers a preconditioning-like effect in heart via a pathway that is dependent on reactive oxygen species. This study examined the signaling pathway by which the NO donor S-nitroso-N-acetylpenicillamine (SNAP, 2 microM) triggers its anti-infarct effect. Isolated rabbit hearts experienced 30 min of regional ischemia and 120 min of subsequent reperfusion. Infarct size was determined by triphenyltetrazolium chloride staining. Infarct size was reduced from 30.5 +/- 3.0… CONTINUE READING

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