Exogenous NO enhances hydrogen peroxide-mediated neutrophil adherence to cultured endothelial cells.

@article{Okayama1998ExogenousNE,
  title={Exogenous NO enhances hydrogen peroxide-mediated neutrophil adherence to cultured endothelial cells.},
  author={Naotsuka Okayama and Hiroshi T. Ichikawa and Laura L Coe and Makoto Itoh and J Steven Jonathan Alexander},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1998},
  volume={274 5},
  pages={L820-L826}
}
One important aspect of oxidant injury is the enhancement of neutrophil-endothelial adhesion by oxidants such as hydrogen peroxide. Recent studies suggest that nitric oxide (NO) can limit oxidant-mediated tissue injury, since inhibitors of endogenous NO synthesis often promote neutrophil-endothelial adhesion. However, less is known about the direct role of exogenous NO in modulating proadhesive effects of oxidants. The objective of this study was to examine how an NO donor modifies hydrogen… CONTINUE READING

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