Exogenous N-acetylglucosamine increases hyaluronan production in cultured human dermal fibroblasts

@article{Tu2009ExogenousNI,
  title={Exogenous N-acetylglucosamine increases hyaluronan production in cultured human dermal fibroblasts},
  author={Cai-xia Tu and Rong-xin Zhang and Xin-Jun Zhang and Tian Huang},
  journal={Archives of Dermatological Research},
  year={2009},
  volume={301},
  pages={549-551}
}
Application of hyaluronan (HA) containing cosmetic products to the skin is reported to moisturize and restore elasticity thereby achieving an antiwrinkle effect. In the skin, HA can be synthesized by dermal fibroblasts and N-acetylglucosamine (NAG) is a precursor for HA biosynthesis in the body. To study the effects of exogenous NAG on HA production in human dermal fibroblasts, HA production and HA-synthesizing enzymes 1, 2 and 3 mRNA expression in cultured human dermal fibroblasts were… CONTINUE READING

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