Exogenous Microparticles of Iron Oxide Bind to Activated Endothelial Cells but, Unlike Monocytes, Do Not Trigger an Endothelial Response

@inproceedings{Jefferson2013ExogenousMO,
  title={Exogenous Microparticles of Iron Oxide Bind to Activated Endothelial Cells but, Unlike Monocytes, Do Not Trigger an Endothelial Response},
  author={Andrew Jefferson and Neil Ruparelia and Robin Choudhury},
  booktitle={Theranostics},
  year={2013}
}
Targeting particles to sites of inflammation is of considerable interest for applications relating to molecular imaging and drug delivery. We and others have described micron-sized particles of iron oxide (MPIO) that can be directed using specific ligands (e.g. antibodies, peptides and oligosaccharides) to bind to mediators of vascular inflammation in vivo. Since leukocyte binding to these molecules can induce changes in the target cell, an outstanding question has been whether the binding of… CONTINUE READING
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, thrombosis , and vascular inflammation using microparticles of iron oxide

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