Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation.

@article{Kimizuka2004ExogenousII,
  title={Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation.},
  author={Kei Kimizuka and Atsunori Nakao and Michael Andrew Nalesnik and Anthony Jake Demetris and Takashi Uchiyama and Kris Ruppert and Mitchell P. Fink and Donna B Stolz and Noriko Murase},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2004},
  volume={4 4},
  pages={482-94}
}
Interleukin-6 (IL-6) is a pleiotropic acute reactant cytokine involved in inflammatory responses. To explore the role of IL-6 in inflammation, this study examined the efficacy of exogenous IL-6 in preventing intestinal ischemia/reperfusion (I/R) injury associated with small bowel transplantation (SBTx). Syngenic orthotopic SBTx was performed in Lewis rats after 6-h graft preservation in University of Wisconsin (UW) at 4 degrees C. IL-6 mutein (IL-6m, 500 microg/kg), a recombinant molecular… CONTINUE READING