Exogenous IL-1beta induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA axis and prolactin release.

@article{kurlov2006ExogenousII,
  title={Exogenous IL-1beta induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA axis and prolactin release.},
  author={Martina {\vS}kurlov{\'a} and Andrea {\vS}tofkov{\'a} and Jana Jur{\vc}ovi{\vc}ov{\'a}},
  journal={Endocrine regulations},
  year={2006},
  volume={40 4},
  pages={125-8}
}
OBJECTIVE Proinflammatory cytokines IL-1beta, and IL-6 are synthesized in the brain, where they exert local regulatory functions. Our aim was to find out whether, along with the activation of hypothalamo-pituitary-adrenocortical (HPA) axis and prolactin (PRL), the acute systemic enhancement of IL-1beta affects its own production in the hypothalamus as well as that of IL-6. METHOD Forty five minutes after a single i.p. administration of recombinant rat IL-1beta (5 microg/kg) to male Long Evans… CONTINUE READING