Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis.

@article{Wang2015ExogenousIA,
  title={Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis.},
  author={Xia Wang and Jin Gao and Lan Qian and Jing Gao and Shunying Zhu and Mingyuan Wu and Yang Zhang and Wen Guan and Hao Ye and Yan Yu and Wei Han},
  journal={Anti-cancer drugs},
  year={2015},
  volume={26 1},
  pages={35-45}
}
Chemotherapy-induced intestinal mucositis (CIM) is a major dose-limiting side effect of many chemoagents, resulting in weight loss, diarrhea, and even death. The current treatments for CIM are palliative and have limited benefit. Interleukin-1 receptor antagonist is a natural antagonist of interleukin-1. Our previous studies showed the protective effect of recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) on the intestine in mice after 5-fluorouracil chemotherapy. In this study, we… CONTINUE READING
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