Exogenous IL-15 in combination with IL-15R alpha rescues natural killer cells from apoptosis induced by chronic alcohol consumption.

@article{Zhang2009ExogenousII,
  title={Exogenous IL-15 in combination with IL-15R alpha rescues natural killer cells from apoptosis induced by chronic alcohol consumption.},
  author={Hui Zhang and Gary G. Meadows},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 3},
  pages={
          419-27
        }
}
BACKGROUND Chronic alcohol consumption reduces the percentage and number of peripheral natural killer (NK) cells in mice and in humans. The underlying mechanism for these changes is only partly known. We recently found that chronic alcohol consumption inhibits NK cell release from the bone marrow (BM) and that this is associated with a decrease in splenic NK cells. The number of peripheral NK cells is tightly controlled by homeostatic proliferation. It is not known whether this mechanism is… CONTINUE READING
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Innate immunity in alcoholic liver disease.

  • American journal of physiology. Gastrointestinal and liver physiology
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