Exogenous GSH protection during hypoxia-reoxygenation of the isolated rat heart: impact of hypoxia duration.

@article{Seiler2000ExogenousGP,
  title={Exogenous GSH protection during hypoxia-reoxygenation of the isolated rat heart: impact of hypoxia duration.},
  author={Karry Stephen Seiler and Joseph W. Starnes},
  journal={Free radical research},
  year={2000},
  volume={32 1},
  pages={41-55}
}
The objective of this study was to determine the interaction between duration of myocardial hypoxia and presence of exogenous glutathione (GSH) on functional recovery upon subsequent reoxygenation. Isolated perfused rat hearts were subjected to 20, 30, 40, or 50 min hypoxia (HYP), which resulted in a progressive decline in the amount of contractile recovery (% of normoxic rate-pressure product (RPP) and developed pressure) during 30 min reoxygenation. Supplementation with 5 mM GSH throughout… CONTINUE READING