Exogenous GDNF increases the migration of the neural stem cells with no protection against kainic acid-induced excitotoxic cell death in rats.

@article{Yoo2012ExogenousGI,
  title={Exogenous GDNF increases the migration of the neural stem cells with no protection against kainic acid-induced excitotoxic cell death in rats.},
  author={Young-Mi Yoo and C Lee and Yong-Jung Kim},
  journal={Brain research},
  year={2012},
  volume={1486},
  pages={27-38}
}
Glia cell line-derived neurotrophic factor (GDNF) is a potent survival factor for several neuron types. In this study, we have evaluated the utility of adenovirus-based vectors (Ad) and hippocampal neural stem cells (NSCs) as genetic tools for the delivery of a therapeutic protein, GDNF, in hippocampus tissues damaged by kainic acid (KA)-induced… CONTINUE READING