Exogenous Choline Enhances the Synthesis of Acetylcholine Only Under Conditions of Increased Cholinergic Neuronal Activity

@article{Trommer1982ExogenousCE,
  title={Exogenous Choline Enhances the Synthesis of Acetylcholine Only Under Conditions of Increased Cholinergic Neuronal Activity},
  author={Barbara Trommer and Dennis E. Schmidt and L. de Wecker},
  journal={Journal of Neurochemistry},
  year={1982},
  volume={39}
}
Abstract: The effect of choline (60 mg/kg, i.p.) on fluphenazine‐ and pentylenetetrazol‐induced alterations in the concentration of acetylcholine (ACh) and/or the rate of sodium‐dependent high‐affinity choline uptake (HACU) in rat striatum and hippocampus was studied. Systemic administration of the dopamine receptor blocking agent fluphenazine hydrochloride (0.5 mg/kg, i.p.) decreased the concentration of ACh in the striatum; this effect was prevented by the prior administration of choline. The… Expand
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  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1986
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TLDR
It is suggested that supplemental choline enhances evoked ACh release in hippocampus of freely-moving rats and significantly enhanced maximal scopolamine responses by about 55%. Expand
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The synthesis of acetylcholine (ACh) requires choline as the immediate precursor. The free extracellular choline can enter cholinergic neurons through a high affinity and a low affinity transportExpand
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  • Biology, Medicine
  • Journal of neurochemistry
  • 1988
TLDR
Results indicate that, despite an increased production of free choline by brain slices from choline‐supplemented rats, the synthesis of acetylcholine was unaltered, even in the presence of an increased neuronal demand. Expand
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