Exogenous BDNF facilitates strategy set-shifting by modulating glutamate dynamics in the dorsal striatum.

@article{DAmore2013ExogenousBF,
  title={Exogenous BDNF facilitates strategy set-shifting by modulating glutamate dynamics in the dorsal striatum.},
  author={Drew E D'Amore and Brittany A Tracy and Vinay Parikh},
  journal={Neuropharmacology},
  year={2013},
  volume={75},
  pages={312-23}
}
Brain-derived neurotrophic factor (BDNF) signaling via tropomyosin-related kinase B (trkB) receptors exerts modulatory effects on glutamatergic transmission, learning, memory and reward processing. Although the role of BDNF in the regulation of mnemonic and affective/motivational processes is well studied, whether this neurotrophin could also regulate executive functions is not known. In the present study, we assessed the effects of intrastriatal infusions on BDNF (1-100 ng/hemisphere) in mice… CONTINUE READING

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