Exogenous Administration of Low-Dose Lipopolysaccharide Potentiates Liver Fibrosis in a Choline-Deficient l-Amino-Acid-Defined Diet-Induced Murine Steatohepatitis Model

@article{Nakanishi2019ExogenousAO,
  title={Exogenous Administration of Low-Dose Lipopolysaccharide Potentiates Liver Fibrosis in a Choline-Deficient l-Amino-Acid-Defined Diet-Induced Murine Steatohepatitis Model},
  author={Keisuke Nakanishi and K. Kaji and M. Kitade and Takuya Kubo and Masanori Furukawa and Soichiro Saikawa and Naotaka Shimozato and Shinya Sato and K. Seki and H. Kawaratani and Kei Moriya and T. Namisaki and H. Yoshiji},
  journal={International Journal of Molecular Sciences},
  year={2019},
  volume={20}
}
Various rodent models have been proposed for basic research; however, the pathogenesis of human nonalcoholic steatohepatitis (NASH) is difficult to closely mimic. Lipopolysaccharide (LPS) has been reported to play a pivotal role in fibrosis development during NASH progression via activation of toll-like receptor 4 (TLR4) signaling. This study aimed to clarify the impact of low-dose LPS challenge on NASH pathological progression and to establish a novel murine NASH model. C57BL/6J mice were fed… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet.
TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice
TLR4 enhances TGF-β signaling and hepatic fibrosis
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2.
...
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2
3
4
5
...