Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication.

@article{Mossel2005ExogenousAE,
  title={Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication.},
  author={Eric C. Mossel and Cheng Huang and Krishna Shankara Narayanan and Shinji Makino and Robert B. Tesh and Clarence J. Peters},
  journal={Journal of virology},
  year={2005},
  volume={79 6},
  pages={3846-50}
}
Of 30 cell lines and primary cells examined, productive severe acute respiratory syndrome coronavirus (Urbani strain) (SARS-CoV) infection after low-multiplicity inoculation was detected in only six: three African green monkey kidney epithelial cell lines (Vero, Vero E6, and MA104), a human colon epithelial line (CaCo-2), a porcine kidney epithelial line [PK(15)], and mink lung epithelial cells (Mv 1 Lu). SARS-CoV produced a lytic infection in Vero, Vero E6, and MA104 cells, but there was no… CONTINUE READING

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