Exogenous, but not endogenous, nitric oxide increases proliferation rates in senescent human fibroblasts.

@article{Gansauge1997ExogenousBN,
  title={Exogenous, but not endogenous, nitric oxide increases proliferation rates in senescent human fibroblasts.},
  author={Susanne Gansauge and Frank Gansauge and Andreas K Nussler and Bettina Rau and Bertram Poch and Michael Schoenberg and Hans G{\"u}nther Beger},
  journal={FEBS letters},
  year={1997},
  volume={410 2-3},
  pages={160-4}
}
We investigated the effects of endogenously produced and exogenously applied nitric oxide (NO) on cell proliferation rates and cell cycle regulation in senescent human fibroblasts (WI38). Induction of inducible nitric oxide synthase by tumor necrosis factor-alpha, interferon-gamma and interleukin-1beta inhibited cell proliferation and led to a G1 arrest. These effects were partially reversible by N(G)-monomethyl-arginine (NMA). Addition of the NO donors sodium nitroprusside (SNP) or S-nitroso-N… CONTINUE READING
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