Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression.

@article{Kronenberg2012ExofocalDD,
  title={Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression.},
  author={Golo Kronenberg and Mustafa Balkaya and Vincent Prinz and Karen Gertz and Shengbo Ji and Imke Kirste and Isabella Heuser and Bj{\"o}rn Kampmann and Julian Hellmann-Regen and Peter Gass and Reinhard Sohr and Rainer Hellweg and Christian Waeber and Georg Juckel and Heide H{\"o}rtnagl and Ralf Stumm and Matthias Endres},
  journal={Biological psychiatry},
  year={2012},
  volume={72 4},
  pages={273-81}
}
BACKGROUND Although poststroke depression (PSD) is a frequent chronic complication of stroke with high relevance for outcome and survival, underlying pathomechanisms remain inadequately understood. This may be because suitable animal models are largely lacking and existing models are poorly characterized. METHODS Male 129/SV mice were subjected to 30-min middle cerebral artery occlusion (MCAo)/reperfusion and serial magnetic resonance imaging scans. A subset of animals received selective… CONTINUE READING
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