Exocytosis-related genes and response to methylphenidate treatment in adults with ADHD

@article{Silva2018ExocytosisrelatedGA,
  title={Exocytosis-related genes and response to methylphenidate treatment in adults with ADHD},
  author={Bruna Soares da Silva and Renata Basso Cupertino and Diego Luiz Rovaris and Jaqueline Bohrer Schuch and Djenifer B. Kappel and Daniela Virote Kassick M{\"u}ller and Cibele Edom Bandeira and Marcelo Moraes Victor and Rafael Gomes Karam and Nina Roth Mota and Luis Augusto Rohde and Ver{\^o}nica Contini and Eugenio Horacio Grevet and Claiton Henrique Dotto Bau},
  journal={Molecular Psychiatry},
  year={2018},
  volume={23},
  pages={1446-1452}
}
Experimental studies have demonstrated that methylphenidate (MPH) modulates the synaptic vesicle trafficking and synaptotagmin-1 (SytI) mRNA levels. SytI is a regulatory protein of the SNARE complex, a neurotransmitter exocytosis mediator. Despite this evidence, most SNARE complex-related genes have never been evaluated in attention-deficit/hyperactivity disorder (ADHD) pharmacogenetics. This study evaluates, for we believe the first time, polymorphisms on the SNARE complex-related genes STX1A… CONTINUE READING
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