Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.

@article{Mead2005ExocytosisOC,
  title={Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.},
  author={Karen I. Mead and Yong Zheng and Claire N. Manzotti and Laura C A Perry and Michael K. P. Liu and Fiona Burke and Dale J. Powner and Michael J O Wakelam and David M Sansom},
  journal={Journal of immunology},
  year={2005},
  volume={174 8},
  pages={4803-11}
}
CTLA-4 is an essential protein in the regulation of T cell responses that interacts with two ligands found on the surface of APCs (CD80 and CD86). CTLA-4 is itself poorly expressed on the T cell surface and is predominantly localized to intracellular compartments. We have studied the mechanisms involved in the delivery of CTLA-4 to the cell surface using a model Chinese hamster ovary cell system and compared this with activated and regulatory human T cells. We have shown that expression of CTLA… CONTINUE READING
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