Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells.

@article{Loffing1998ExocytosisIN,
  title={Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells.},
  author={Johannes Loffing and Bryan D Moyer and David E. McCoy and Bruce A. Stanton},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 4},
  pages={C913-C920}
}
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel, which mediates transepithelial Cl- transport in a variety of epithelia, including airway, intestine, pancreas, and sweat duct. In some but not all epithelial cells, cAMP stimulates Cl- secretion in part by increasing the number of CFTR Cl- channels in the apical plasma membrane. Because the mechanism whereby cAMP stimulates CFTR Cl- secretion is cell-type specific, our goal was… CONTINUE READING

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