Exocyst Sec5 Regulates Exocytosis of Newcomer Insulin Granules Underlying Biphasic Insulin Secretion

@inproceedings{Xie2013ExocystSR,
  title={Exocyst Sec5 Regulates Exocytosis of Newcomer Insulin Granules Underlying Biphasic Insulin Secretion},
  author={Li Xie and Dan Zhu and Youhou Kang and Tao Liang and Yu He and Herbert Y Gaisano},
  booktitle={PloS one},
  year={2013}
}
The exocyst complex subunit Sec5 is a downstream effector of RalA-GTPase which promotes RalA-exocyst interactions and exocyst assembly, serving to tether secretory granules to docking sites on the plasma membrane. We recently reported that RalA regulates biphasic insulin secretion in pancreatic islet β cells in part by tethering insulin secretory granules to Ca(2+) channels to assist excitosome assembly. Here, we assessed β cell exocytosis by patch clamp membrane capacitance measurement and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Exocytosis function is regulated by effector phosphorylation

XW Chen, D Leto, J Xiao, J Goss, Q Wang
  • Nat cell biol
  • 2011
VIEW 1 EXCERPT

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